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pentobarbital will lower the level or outcome of flurbiprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Unidentified.pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May perhaps cause lack of virologic response